Secondary Metabolites from Astragalus lycius and Their Cytotoxic Activities

Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5′-dihydroxy-3′-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4′-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5...

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Bibliographic Details
Published in:Natural product communications 2016-12, Vol.11 (12), p.1847-1850
Main Authors: Horo, Ibrahim, Kocabaş, Fatma, Alankuş-Çalışkan, Özgen, Özgökçe, Fevzi, Khan, Ihlas A., Bedir, Erdal
Format: Article
Language:English
Subjects:
Antineoplastic Agents - analysis
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Astragalus Plant - metabolism
Cell Line
Cell Survival - drug effects
Humans
Phytochemicals - analysis
Phytochemicals - metabolism
Phytochemicals - pharmacology
Secondary Metabolism
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Summary:Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5′-dihydroxy-3′-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4′-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3-O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1–7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601101218