Association between trace elements levels and asthma susceptibility

It is well-documented that the dysregulation of trace elements may be involved in the pathogenesis of asthma. However, the precise changes of trace elements levels in asthma cases remain elusive. We established whether trace elements levels were associated with asthma susceptibility by pooling case-...

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Bibliographic Details
Published in:Respiratory medicine 2018-12, Vol.145, p.110-119
Main Authors: Mao, Song, Wu, Liangxia, Shi, Wenjing
Format: Article
Language:English
Subjects:
Age
Asthma
Bias
Biomarkers
Confidence intervals
Control methods
Copper
Ethnicity
Gender
Homeostasis
Iron
Levels
Magnesium
Oxidative stress
Population studies
Populations
Quality
Selenium
Sensitivity analysis
Statistical analysis
Systematic review
Trace elements
White people
Zinc
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Summary:It is well-documented that the dysregulation of trace elements may be involved in the pathogenesis of asthma. However, the precise changes of trace elements levels in asthma cases remain elusive. We established whether trace elements levels were associated with asthma susceptibility by pooling case-control studies. 34 studies were included. We extracted the standard mean differences (SMDs) and corresponding 95% confidence intervals (CIs). A pooled-analysis was performed. No marked difference (95% CI: -1.437–0.218, p = 0.149) of Se level between asthma and controls. Significant difference (95% CI: 0.112–1.032, p = 0.015; 95% CI: 0.376–1.331, p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2018.10.028