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Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review

In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive...

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Bibliographic Details
Published in:Cardiology in the young 2019-02, Vol.29 (2), p.241-243
Main Authors: Rodriguez-Gonzalez, Moises, Ruiz-Gonzalez, Estefania, Castellano-Martinez, Ana
Format: Article
Language:English
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Summary:In approximately 5% of patients with idiopathic recurrent pericarditis, the disease usually follows a chronic relapsing course, and children can develop dependence and side effects of prolonged high-dose corticosteroid regimens. In this setting anakinra, a recombinant human interleukin-1 competitive receptor antagonist that blocks the biologic effects of interleukin-1, thereby reducing systemic inflammatory responses, appears to be one of the most promising strategies. We report an adolescent with steroid-dependent idiopathic recurrent pericarditis that was successfully treated with anakinra, highlighting that this therapeutic option seems to be an effective, rapidly acting, steroid-sparing, and relatively safe agent for the treatment of this entity in children.
ISSN:1047-9511
1467-1107
DOI:10.1017/S1047951118002020