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Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia
Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate...
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Published in: | The Journal of nutritional biochemistry 2019-02, Vol.64, p.162-169 |
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creator | Huang, Fengyang del-Río-Navarro, Blanca Estela Leija-Martinez, José Torres-Alcantara, Saúl Ruiz-Bedolla, Eliseo Hernández-Cadena, Leticia Barraza-Villarreal, Albino Romero-Nava, Rodrigo Sanchéz-Muñoz, Fausto Villafaña, Santiago Marchat, Laurence A. Hong, Enrique |
description | Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents. |
doi_str_mv | 10.1016/j.jnutbio.2018.10.012 |
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The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2018.10.012</identifier><identifier>PMID: 30513433</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipokines ; Adipokines - blood ; ADMA ; Adolescent ; Biomarkers - blood ; Child ; Dietary Supplements ; Double-Blind Method ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiopathology ; Fatty Acids, Omega-3 - therapeutic use ; Healthy Lifestyle ; Humans ; Hypertriglyceridemia - diet therapy ; Lifestyle intervention ; Obese adolescents ; Obesity - physiopathology ; Obesity - therapy ; Omega-3 ; Regression Analysis ; Treatment Outcome ; Triglycerides - blood</subject><ispartof>The Journal of nutritional biochemistry, 2019-02, Vol.64, p.162-169</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-698beb7353da947c3fb1eb9393ad2c2b5bd6ca4735532e223aa28d72dc0b5e2b3</citedby><cites>FETCH-LOGICAL-c365t-698beb7353da947c3fb1eb9393ad2c2b5bd6ca4735532e223aa28d72dc0b5e2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30513433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Fengyang</creatorcontrib><creatorcontrib>del-Río-Navarro, Blanca Estela</creatorcontrib><creatorcontrib>Leija-Martinez, José</creatorcontrib><creatorcontrib>Torres-Alcantara, Saúl</creatorcontrib><creatorcontrib>Ruiz-Bedolla, Eliseo</creatorcontrib><creatorcontrib>Hernández-Cadena, Leticia</creatorcontrib><creatorcontrib>Barraza-Villarreal, Albino</creatorcontrib><creatorcontrib>Romero-Nava, Rodrigo</creatorcontrib><creatorcontrib>Sanchéz-Muñoz, Fausto</creatorcontrib><creatorcontrib>Villafaña, Santiago</creatorcontrib><creatorcontrib>Marchat, Laurence A.</creatorcontrib><creatorcontrib>Hong, Enrique</creatorcontrib><title>Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. 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In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.</description><subject>Adipokines</subject><subject>Adipokines - blood</subject><subject>ADMA</subject><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Healthy Lifestyle</subject><subject>Humans</subject><subject>Hypertriglyceridemia - diet therapy</subject><subject>Lifestyle intervention</subject><subject>Obese adolescents</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Omega-3</subject><subject>Regression Analysis</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkUuLFDEUhYMoTjv6E5Qs3VSbR6W6aiUyjA8YcKPrkMet6fSkkjJJjdRP89-Zslu3QiBw-c4993AQek3JnhLavTvtT2Ep2sU9I7Svsz2h7Ana0f7Am7ZvD0_RjgxCNKzv-BV6kfOJEMJa0T1HV5wIylvOd-jX7TiCKTiOOE5wrxqOR1XKipVxNuO8zLOHCUJRxcWATZy0C2DxT1eO2LsRclk9YBcKpMeKbVB9yro5PlQyYxUsrmdOKj1AypsRBBvLEbxTHts1j0swf3SuSjVkqOroIZu6Lp-NjusMqSR371cDyVmYnHqJno3KZ3h1-a_R94-3324-N3dfP325-XDXGN6J0nRDr0EfuOBWDe3B8FFT0AMfuLLMMC207YxqKyA4A8a4Uqy3B2YN0QKY5tfo7XnvnOKPpeaVk6u3ea8CxCVLRgURbGBtX1FxRk2KOScY5ZxcDb5KSuTWmjzJS2tya20b19aq7s3FYtET2H-qvzVV4P0ZgBr00UGS2TgIBqxLtT1po_uPxW_BZ7JI</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Huang, Fengyang</creator><creator>del-Río-Navarro, Blanca Estela</creator><creator>Leija-Martinez, José</creator><creator>Torres-Alcantara, Saúl</creator><creator>Ruiz-Bedolla, Eliseo</creator><creator>Hernández-Cadena, Leticia</creator><creator>Barraza-Villarreal, Albino</creator><creator>Romero-Nava, Rodrigo</creator><creator>Sanchéz-Muñoz, Fausto</creator><creator>Villafaña, Santiago</creator><creator>Marchat, Laurence A.</creator><creator>Hong, Enrique</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia</title><author>Huang, Fengyang ; del-Río-Navarro, Blanca Estela ; Leija-Martinez, José ; Torres-Alcantara, Saúl ; Ruiz-Bedolla, Eliseo ; Hernández-Cadena, Leticia ; Barraza-Villarreal, Albino ; Romero-Nava, Rodrigo ; Sanchéz-Muñoz, Fausto ; Villafaña, Santiago ; Marchat, Laurence A. ; Hong, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-698beb7353da947c3fb1eb9393ad2c2b5bd6ca4735532e223aa28d72dc0b5e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipokines</topic><topic>Adipokines - blood</topic><topic>ADMA</topic><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Healthy Lifestyle</topic><topic>Humans</topic><topic>Hypertriglyceridemia - diet therapy</topic><topic>Lifestyle intervention</topic><topic>Obese adolescents</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Omega-3</topic><topic>Regression Analysis</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Fengyang</creatorcontrib><creatorcontrib>del-Río-Navarro, Blanca Estela</creatorcontrib><creatorcontrib>Leija-Martinez, José</creatorcontrib><creatorcontrib>Torres-Alcantara, Saúl</creatorcontrib><creatorcontrib>Ruiz-Bedolla, Eliseo</creatorcontrib><creatorcontrib>Hernández-Cadena, Leticia</creatorcontrib><creatorcontrib>Barraza-Villarreal, Albino</creatorcontrib><creatorcontrib>Romero-Nava, Rodrigo</creatorcontrib><creatorcontrib>Sanchéz-Muñoz, Fausto</creatorcontrib><creatorcontrib>Villafaña, Santiago</creatorcontrib><creatorcontrib>Marchat, Laurence A.</creatorcontrib><creatorcontrib>Hong, Enrique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Fengyang</au><au>del-Río-Navarro, Blanca Estela</au><au>Leija-Martinez, José</au><au>Torres-Alcantara, Saúl</au><au>Ruiz-Bedolla, Eliseo</au><au>Hernández-Cadena, Leticia</au><au>Barraza-Villarreal, Albino</au><au>Romero-Nava, Rodrigo</au><au>Sanchéz-Muñoz, Fausto</au><au>Villafaña, Santiago</au><au>Marchat, Laurence A.</au><au>Hong, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2019-02</date><risdate>2019</risdate><volume>64</volume><spage>162</spage><epage>169</epage><pages>162-169</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30513433</pmid><doi>10.1016/j.jnutbio.2018.10.012</doi><tpages>8</tpages></addata></record> |
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subjects | Adipokines Adipokines - blood ADMA Adolescent Biomarkers - blood Child Dietary Supplements Double-Blind Method Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Fatty Acids, Omega-3 - therapeutic use Healthy Lifestyle Humans Hypertriglyceridemia - diet therapy Lifestyle intervention Obese adolescents Obesity - physiopathology Obesity - therapy Omega-3 Regression Analysis Treatment Outcome Triglycerides - blood |
title | Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia |
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