TPO-Ab plays a role in arterial remodeling in patients with intracranial stenosis

Intracranial stenosis (ICS), the common cause of ischemic stroke worldwide, is associated with a high risk of recurrent stroke. We aimed to investigate the relationship between arterial remodeling and antithyroid peroxidase-antibody (TPO-Ab) level in ICS and the effect of TPO-Ab level on the migrati...

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Bibliographic Details
Published in:Atherosclerosis 2019-01, Vol.280, p.140-146
Main Authors: Zhang, Xuting, Zhou, Ying, Ding, Wenhong, Zhang, Ruiting, Yan, Shenqiang, Deng, Yujie, Gao, Feng, Lou, Min
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Animals
Antithyroid peroxidase antibody
Aorta, Thoracic - metabolism
Arterial remodeling
Arteries - physiopathology
Autoantibodies - immunology
Cell Movement
Cerebrovascular Circulation
Constriction, Pathologic - immunology
Female
Humans
Intracranial stenosis
Iodide Peroxidase - immunology
Ischemic Attack, Transient - immunology
Ischemic Attack, Transient - physiopathology
Magnetic Resonance Imaging
Male
Middle Aged
Migration
Muscle, Smooth, Vascular - cytology
Prospective Studies
Rats
Rats, Sprague-Dawley
Retrospective Studies
Thyroid Gland - metabolism
Vascular Remodeling
Vascular smooth muscle cells
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Summary:Intracranial stenosis (ICS), the common cause of ischemic stroke worldwide, is associated with a high risk of recurrent stroke. We aimed to investigate the relationship between arterial remodeling and antithyroid peroxidase-antibody (TPO-Ab) level in ICS and the effect of TPO-Ab level on the migration of vascular smooth muscle cells (VSMCs). We analyzed data of mild-to-severe ICS patients with normal thyroid function who underwent high-resolution magnetic resonance imaging in our center. Vessel area (VA), lumen area, wall area and plaque size were assessed at the most narrowed lumen (MNL) and reference site, respectively. The remodeling index (RI) was defined as VAMNL/VAreference. Negative remodeling (NR) or non-NR was defined as RI ≤ 0.95 or > 0.95. A scratch-wound healing assay was also designed to analyze the impact of TPO-Ab level on migration of VSMCs, which were isolated from thoracic aorta segments of Sprague Dawley rats. A total of 88 patients were included. Patients with elevated TPO-Ab had smaller VA, wall area, plaque size and RI than those with normal level (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2018.11.032