The effects of oxytocin on penile tissues in experimental priapism model in rats

Purpose This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia–reperfusion injury developed after priapism. Methods Forty Wistar Albino strain male rats were divided into four groups. The control group ( n  = 10) was not intervened. In Group 2, a rat model of priapism...

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Bibliographic Details
Published in:International urology and nephrology 2019-02, Vol.51 (2), p.231-238
Main Authors: Kolukcu, Engin, Kilic, Sahin, Parlaktas, Bekir Suha, Erdemir, Fikret, Unsal, Velid, Atılgan, Dogan, Uluocak, Nihat
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Edema
Genital diseases
Glutathione peroxidase
Glutathione Peroxidase - blood
Ischemia
Male
Malondialdehyde
Malondialdehyde - blood
Medicine
Medicine & Public Health
Nephrology
Nitric oxide
Nitric Oxide - blood
Oxytocin
Oxytocin - metabolism
Penis
Penis - blood supply
Penis - metabolism
Penis - pathology
Priapism - complications
Protective Factors
Rats
Rats, Wistar
Reperfusion
Reperfusion Injury - etiology
Reperfusion Injury - metabolism
Rodents
Severity of Illness Index
Statistical analysis
Superoxide dismutase
Superoxide Dismutase - blood
Time Factors
Urology
Urology - Original Paper
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Summary:Purpose This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia–reperfusion injury developed after priapism. Methods Forty Wistar Albino strain male rats were divided into four groups. The control group ( n  = 10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30 min following priapism. Rats in Group 4 rats were given oxytocin 30 min before the induction of reperfusion following priapism. All rats were penectomized, and adequate amounts of blood sample were drawn. Inflammation, vasocongestion, desquamation, and edema in penile tissue were scored between 0 and 3 points (0: normal, 1: mild, 2: moderate, 3: severe) to evaluate the severity of tissue damage. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA), and nitric oxide (NO) in blood samples were determined spectrophotometrically. Results In histopathological examination, statistically significant positive changes were detected in vasocongestion, inflammation, desquamation, and edema scores in Group 4 than in Group 2 and Group 3 ( p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-018-2046-z