Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simpl...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018-12, Vol.16 (48), p.9487-9491
Main Authors: Shi, Tianchao, Qin, Feng, Li, Qian, Zhang, Wu
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Atom economy
Chemical synthesis
Copper
Copper compounds
Functional groups
NMR
Nuclear magnetic resonance
Pyrimidines
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Summary:An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simplicity.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02694g