Genotoxic effects of nanosized and fine TiO2

The in-vitro genotoxicity of nanosized TiO2 rutile and anatase was assessed in comparison with fine TiO2 rutile in human bronchial epithelial BEAS 2B cells using the single-cell gel electrophoresis (comet) assay and the cytokinesis-block micronucleus test. BEAS 2B cells were exposed to eight doses (...

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Bibliographic Details
Published in:Human & experimental toxicology 2009-06, Vol.28 (6-7), p.339-352
Main Authors: Falck, GCM, Lindberg, HK, Suhonen, S., Vippola, M., Vanhala, E., Catalán, J., Savolainen, K., Norppa, H.
Format: Article
Language:English
Subjects:
Cell Line
Chemicals
Comet Assay
Culture Media
DNA Damage
Dose-Response Relationship, Drug
Health risk assessment
Human exposure
Humans
Micronucleus Tests
Mutagens - toxicity
Nanomaterials
Nanoparticles
Occupational health
Titanium - toxicity
Toxicology
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Summary:The in-vitro genotoxicity of nanosized TiO2 rutile and anatase was assessed in comparison with fine TiO2 rutile in human bronchial epithelial BEAS 2B cells using the single-cell gel electrophoresis (comet) assay and the cytokinesis-block micronucleus test. BEAS 2B cells were exposed to eight doses (1—100 μg/cm2) of titanium(IV) oxide nanosized rutile (>95%,
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327109105163