Simpotentin, a new potentiator of amphotericin B activity against Candida albicans, produced by Simplicillium minatense FKI-4981

Simpotentin, a new potentiator of amphotericin B activity against Candida albicans and Cryptococcus neoformans , was isolated from the culture broth of Simplicillium minatense FKI-4981 by Diaion HP-20 column chromatography, centrifugal partition chromatography, and preparative HPLC. The structure of...

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Bibliographic Details
Published in:Journal of antibiotics 2019-03, Vol.72 (3), p.134-140
Main Authors: Uchida, Ryuji, Kondo, Ariko, Yagi, Akiho, Nonaka, Kenichi, Masuma, Rokurou, Kobayashi, Keisuke, Tomoda, Hiroshi
Format: Article
Language:English
Subjects:
631/154/1435/2417
631/92/507
Amphotericin B - pharmacology
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Candida albicans - drug effects
Candida albicans - growth & development
Chromatography
Chromatography - methods
Comparative analysis
Cryptococcus neoformans - drug effects
Cryptococcus neoformans - growth & development
Culture Media - chemistry
Drug Synergism
Fungal infections
Health risk assessment
Hypocreales - metabolism
Life Sciences
Liquid chromatography
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medicinal Chemistry
Microbial Sensitivity Tests
Microbiology
Organic Chemistry
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Summary:Simpotentin, a new potentiator of amphotericin B activity against Candida albicans and Cryptococcus neoformans , was isolated from the culture broth of Simplicillium minatense FKI-4981 by Diaion HP-20 column chromatography, centrifugal partition chromatography, and preparative HPLC. The structure of simpotentin was elucidated by spectroscopic analyses including NMR and MS. The compound has a mannose core to which two medium-chain fatty acids are linked. Simpotentin was found to potentiate amphotericin B activity against C. albicans by the microdilution method.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-018-0128-x