Sex-specific association between serum immunoglobulin-M and brachial ankle pulse wave velocity in a Chinese population: Danyang Study

Emerging evidence supports a causal role for the immunoglobulin-M (IgM) as a protector of atherosclerosis. Since arterial stiffness is an index of subclinical atherosclerosis, we propose that IgM may play an important role in arterial stiffness. As the level of IgM differs between sexes, we investig...

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Bibliographic Details
Published in:Hypertension research 2019-03, Vol.42 (3), p.385-391
Main Authors: Liu, Ming, Yao, Yangjing, Zhu, Tianxiang, Xie, Yong, Zhang, Siqi, Sun, Yunfei, Xia, Lili, Wu, Ziyu, Huang, Qing, Fang, Zhuyuan
Format: Article
Language:English
Subjects:
Ankle
Atherosclerosis
Hormone replacement therapy
Immunoglobulins
Regression analysis
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Summary:Emerging evidence supports a causal role for the immunoglobulin-M (IgM) as a protector of atherosclerosis. Since arterial stiffness is an index of subclinical atherosclerosis, we propose that IgM may play an important role in arterial stiffness. As the level of IgM differs between sexes, we investigate the sex-specific association of serum IgM with arterial stiffness in a Chinese population. The study subjects were recruited from Danyang in 2017. Using the Omron VP-1000 system, we measured brachial ankle pulse wave velocity (baPWV). Serum IgM concentration was measured by the immunoturbidimetry method. The 1030 study participants (mean age = 54.3 ± 9.0 years) included 407 men (39.5%), 428 hypertensive (41.6%), 80 diabetic (7.8%), and 512 arterial stiffness patients (49.7%). Serum IgM concentration was lower in men than women (0.97 vs. 1.26 μg/mL, P 
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-018-0156-8