A multicenter, prospective evaluation of the Chinese Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation

• Published in: Thrombosis research 2019-01, Vol.173, p.131-140
• Main Authors: Luo, Lili, Wu, Yingying, Niu, Ting, Han, Yue, Feng, Ying, Ding, Qiulan, Huang, Ruibin, Zhang, Xiaohui, Feng, Jianming, Hou, Ming, Peng, Jun, Li, Yan, Zhou, Yuhong, Su, Lei, Yang, Linhua, Zhou, Zeping, Xue, Feng, Gu, Jian, Zhu, Tienan, Wang, Xiaomin, Deng, Jun, Mei, Heng, Hu, Yu
• Format: Article
• Language: English
• Subjects: Criteria; Diagnosis; Disseminated intravascular coagulation (DIC); Prognosis; Scoring system
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2018.11.022

Disseminated intravascular coagulation (DIC) is a severe complication of critical conditions. There are several scoring systems used for the diagnosis of DIC, including the International Society on Thrombosis and Hemostasis (ISTH) Overt-DIC criteria, the Japanese Ministry of Health and Welfare (JMHW) criteria and the Chinese Society of Thrombosis and Hemostasis scoring system for DIC (CDSS). The objective of this prospective study was to evaluate the accuracy and predictive value of the CDSS. 1318 patients, aged 18–70 years old and suspected of DIC were enrolled from 18 hospitals across China. Participants were divided into two groups for analysis (group 1, non-hematological diseases; group 2, hematological diseases). 242 patients were excluded because of incomplete data collection and failure to follow-up. The rates of concordance of diagnosis of DIC between the CDSS and two other scoring systems were close to 80%. The area under ROC curves of CDSS had a slight advantage when using the ISTH, JMHW criteria or prognosis as gold standard, respectively. The CDSS DIC was an independent predictor of mortality, and its odds-ratio was superior or comparable to that of the ISTH and JMHW criteria in the two groups. The CDSS DIC score also had a significant correlation with the APACHE II and SOFA score (p