Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study

This study aimed to assess the association between two tag single nucleotide polymorphisms (SNPs) (rs68177277 and rs11624293) of G protein-coupled receptor 65 (GPR65) gene and ankylosing spondylitis (AS) susceptibility in a Chinese Han population. 673 patients with AS diagnosed according to the modi...

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Bibliographic Details
Published in:Human immunology 2019-02, Vol.80 (2), p.146-150
Main Authors: Yuan, Yaping, Ma, Yubo, Zhang, Xu, Han, Renfang, Hu, Xingxing, Yang, Jiajia, Wang, Mengmeng, Guan, Shi-Yang, Pan, Guixia, Xu, Sheng-qian, Jiang, Shanqun, Pan, Faming
Format: Article
Language:English
Subjects:
Adult
Ankylosing spondylitis
Case-Control Studies
China
Disease Progression
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
GRP65
Humans
Inflammation
Male
Polymorphism, Single Nucleotide
Receptors, G-Protein-Coupled - genetics
Risk
Single nucleotide polymorphisms
Spondylitis, Ankylosing - genetics
Young Adult
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Summary:This study aimed to assess the association between two tag single nucleotide polymorphisms (SNPs) (rs68177277 and rs11624293) of G protein-coupled receptor 65 (GPR65) gene and ankylosing spondylitis (AS) susceptibility in a Chinese Han population. 673 patients with AS diagnosed according to the modified New York criteria and 679 age- and gender-matched healthy controls were recruited. SNP genotyping for rs68177277 and rs11624293 polymorphisms were performed using the SNPscan technique. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Genotype and allele distribution of rs11624293 but not rs68177277 were significantly different between AS and controls (p = 0.004 and p = 0.002). Compared to the wild-type T/T genotype and T allele at rs11624293, the frequencies of C/T genotype and C allele were significantly higher in AS than controls after adjusting for age and gender (OR = 1.527, 95%CIs: 1.190–1.958; OR = 1.515, 95%CIs: 1.183–1.942, respectively). Dominant and co-dominant model of rs11624293 were predictive of AS susceptibility. In AS patients, the genotype of rs11624293 was significantly associated with BASFI scores in those with low disease activity (BASDAI 
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2018.12.001