The relationship between endothelial function and aortic valve calcification: Multi-Ethnic Study of Atherosclerosis

Aortic valve calcification (AVC) may be associated with atherogenic processes arising from endothelial dysfunction (ED). Limited data is available about the relationship between ED, defined by flow mediated dilation (FMD%) and biomarkers, and the prevalence and progression of AVC in a multiethnic po...

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Bibliographic Details
Published in:Atherosclerosis 2019-01, Vol.280, p.155-165
Main Authors: Abd alamir, Moshrik, Goyfman, Michael, Johnson, Dana, Liu, Yangyang, Dabbous, Firas, Chaus, Adib, Budoff, Mathew
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aortic Valve - pathology
Aortic Valve - physiopathology
Aortic valve calcification
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - ethnology
Aortic Valve Stenosis - physiopathology
Atherosclerosis - complications
Atherosclerosis - ethnology
Atherosclerosis - physiopathology
Biomarkers
Biomarkers - analysis
C-Reactive Protein - analysis
Calcinosis - complications
Calcinosis - ethnology
Calcinosis - physiopathology
Disease Progression
E-Selectin - analysis
Endothelial dysfunction
Endothelium, Vascular - physiopathology
Ethnic Groups
Female
Fibrinogen - analysis
FMD
Humans
Intercellular Adhesion Molecule-1 - analysis
Male
Middle Aged
Multivariate Analysis
Prevalence
Prospective Studies
Risk Factors
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Summary:Aortic valve calcification (AVC) may be associated with atherogenic processes arising from endothelial dysfunction (ED). Limited data is available about the relationship between ED, defined by flow mediated dilation (FMD%) and biomarkers, and the prevalence and progression of AVC in a multiethnic population. A sample of 3475 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with both initial and repeat CT scans at a mean of 2.65 ± 0.84 years and FMD% and serologic markers of ED [ C-reactive protein (CRP), Von Willebrand factor (vWF), Plasminogen Activator Inhibitor (PAI), fibrinogen, Interleukin 6 (IL6), E-selectin and ICAM-1 (Intercellular Adhesion Molecule 1)], were analyzed. Multivariate modeling evaluated the association between ED and the prevalent AVC and AVC progression. The median levels of FMD% was lower and vWF%, fibrinogen, IL6 and ICAM-1 were significantly higher in the AVC prevalence group versus no AVC prevalence (all p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2018.11.029