Relapse in children with clinical stage I testicular yolk sac tumors after initial orchiectomy

Purpose To evaluate risk factors of relapse in pediatric patients with clinical stage I (CS1) testicular yolk sac tumors. Methods With retrospective analysis, the medical records of children with pure testicular yolk sac tumors who were referred to Sun Yat-sen University Cancer Center and The First...

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Bibliographic Details
Published in:Pediatric surgery international 2019-03, Vol.35 (3), p.383-389
Main Authors: Ye, Yun-lin, Zheng, Fu-fu, Chen, Dong, Zhang, Ji, Liu, Zhuo-wei, Qin, Zi-ke, Zhou, Fang-jian
Format: Article
Language:English
Subjects:
Chemotherapy
Fish
Gangrene
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Surgery
Testicular cancer
Tumors
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Summary:Purpose To evaluate risk factors of relapse in pediatric patients with clinical stage I (CS1) testicular yolk sac tumors. Methods With retrospective analysis, the medical records of children with pure testicular yolk sac tumors who were referred to Sun Yat-sen University Cancer Center and The First Affiliated Hospital from January 1995 to December 2015 were selected and recorded. Histopathology and staging were retrieved and multivariate analysis was performed with SPSS 20.0 software. Results 90 children with CS1 testicular yolk sac tumors were selected, and 21 of them underwent chemotherapy following initial orchiectomy. The median age of them was 17 months. With a median follow-up of 61 months (range 11–183 months), 84 patients were alive and 3 patients died, whereas the status was unknown in 3 patients. 30 patients experienced relapse within a median time of 4 months, including only 1 patient who underwent primary chemotherapy, and 28 of these patients underwent salvage chemotherapy. According to adjusted analysis, lymphovascular invasion (LVI) ( P  
ISSN:0179-0358
1437-9813
DOI:10.1007/s00383-018-04426-5