Guillain–Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity

Objectives To describe the epidemiology and clinical heterogeneity of Guillain–Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS). Methods The incidence rate (IR) of GBS in Denmark from September 2...

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Bibliographic Details
Published in:Journal of neurology 2019-02, Vol.266 (2), p.440-449
Main Authors: Al-Hakem, Helle, Sindrup, Søren H., Andersen, Henning, de la Cour, Charlotte Dornonville, Lassen, Lisbeth L., van den Berg, Bianca, Jacobs, Bart C., Harbo, Thomas
Format: Article
Language:English
Subjects:
Diagnosis
Epidemiology
Guillain-Barre syndrome
Immunoglobulins
Inflammation
Intravenous administration
Medicine
Medicine & Public Health
Neurological diseases
Neurology
Neuropathy
Neuroradiology
Neurosciences
Original Communication
Patients
Population studies
Population-based studies
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Summary:Objectives To describe the epidemiology and clinical heterogeneity of Guillain–Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS). Methods The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course. Results A total of 299 GBS cases were confirmed, corresponding to a crude IR of 1.59 (95% CI 1.42–1.78) per 100,000 per year. The Brighton criteria level 1–3 of diagnostic certainty was met in 279 (93%) of the patients. Thirty-five percent of the patients were mildly affected (GBS disability score 
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-018-9151-x