Commentary on Randomization: The forgotten component of the randomized clinical trial

“We are what we eat.” Raised on a soup of Kempthorne's Chapter 71 (which laid out the basis for inference from randomized clinical trials (RCTs)), Cochran's eminent practicality (don't let arcane theory prevent you from looking at actual data) in his text and classes,2 and Cornfield&#...

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Bibliographic Details
Published in:Statistics in medicine 2019-01, Vol.38 (1), p.14-16
Main Author: Wittes, Janet Turk
Format: Article
Language:English
Subjects:
Clinical outcomes
Clinical trials
Medical statistics
Randomized Controlled Trials as Topic
Research Design
Research methodology
Statistical inference
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Summary:“We are what we eat.” Raised on a soup of Kempthorne's Chapter 71 (which laid out the basis for inference from randomized clinical trials (RCTs)), Cochran's eminent practicality (don't let arcane theory prevent you from looking at actual data) in his text and classes,2 and Cornfield's remarkable ability to experiment with and rethink his views,3 I approach the analysis of RCTs in a somewhat different spirit from that expressed by the provocative paper by Rosenberger, Uschner, and Wang (RUW).4
ISSN:0277-6715
1097-0258
DOI:10.1002/sim.7933