Hydrogen sulfide: Therapeutic or injurious in ischemic stroke?

Hydrogen sulfide (H2S) has been identified as a vasodilatory, neuromodulatory, and anti-inflammatory gasotransmitter with antioxidant properties. Studies focused in cardiac tissue suggest H2S functions as a protective agent; however in the central nervous system (CNS) the effects of H2S during state...

Full description

Saved in:
Bibliographic Details
Published in:Pathophysiology (Amsterdam) 2019-03, Vol.26 (1), p.1-10
Main Authors: Gopalakrishnan, Priya, Shrestha, B., Kaskas, A.M., Green, J., Alexander, J.S., Pattillo, C.B.
Format: Article
Language:English
Subjects:
Hydrogen sulfide
Stroke
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrogen sulfide (H2S) has been identified as a vasodilatory, neuromodulatory, and anti-inflammatory gasotransmitter with antioxidant properties. Studies focused in cardiac tissue suggest H2S functions as a protective agent; however in the central nervous system (CNS) the effects of H2S during states of stress or injury, such as stroke, remain controversial. Currently, the application of H2S donors and modulators in stroke depends on the type of H2S donor and the timing of the therapy.
ISSN:0928-4680
1873-149X
DOI:10.1016/j.pathophys.2018.10.005