Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors

Background Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated cond...

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Bibliographic Details
Published in:Obesity surgery 2019-03, Vol.29 (3), p.953-957
Main Authors: Dias, Lisiane Stefani, Nienov, Otto Henrique, Machado, Fernanda Dapper, Ramos, Camila Perlin, Rodrigues, Daiane, Menguer, Rodrigo Koprovsky, Schmid, Helena
Format: Article
Language:English
Subjects:
Adult
Age
Cross-Sectional Studies
Deficiency Diseases - complications
Deficiency Diseases - epidemiology
Diabetes
Diabetes Mellitus
Female
Gastrointestinal surgery
Humans
Medicine
Medicine & Public Health
Michigan - epidemiology
Obesity
Obesity, Morbid - complications
Obesity, Morbid - epidemiology
Obesity, Morbid - surgery
Original Contribution
Peripheral neuropathy
Polyneuropathies - epidemiology
Polyneuropathies - etiology
Prevalence
Risk Factors
Surgery
Women
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Summary:Background Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. The aim of this study was to evaluate the prevalence of PNP in severely obese (SO) women without DM or common nutritional deficiencies in order to determine factors associated with the presence of PNP. Methods A cross-sectional study was performed on 450 SO women. They were evaluated with the Michigan Neuropathy Screening Instrument, a Sleep Apnea Questionnaire, and the short form of the International Physical Activity Questionnaire. Data on blood pressure, body mass index, waist circumference, serum glucose, glycated hemoglobin, LDL and HDL cholesterol, triglycerides, vitamin B12, and postmenopausal (PM) status were also collected. Patients with DM and other common causes of PNP were excluded. To evaluate which variables were independently associated with PNP (dependent variable), Poisson regression models were used. Results The prevalence of PNP was 11.6%. In univariate analysis, PNP was associated with age, PM status, and diagnosis of systemic arterial hypertension ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-018-03627-0