Trichothecrotocins A–C, Antiphytopathogenic Agents from Potato Endophytic Fungus Trichothecium crotocinigenum

Two trichothecene sesquiterpenoids, trichothecrotocins A (1) and B (2), and a merosesquiterpenoid racemate, (±)-trichothecrotocin C (3), were obtained from potato endophytic fungus Trichothecium crotocinigenum by bioguided isolation. Their structures were elucidated by extensive spectroscopic method...

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Bibliographic Details
Published in:Organic letters 2018-12, Vol.20 (24), p.8069-8072
Main Authors: Yang, Hui-Xiang, Ai, Hong-Lian, Feng, Tao, Wang, Wen-Xuan, Wu, Bin, Zheng, Yong-Sheng, Sun, Huan, He, Juan, Li, Zheng-Hui, Liu, Ji-Kai
Format: Article
Language:English
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Summary:Two trichothecene sesquiterpenoids, trichothecrotocins A (1) and B (2), and a merosesquiterpenoid racemate, (±)-trichothecrotocin C (3), were obtained from potato endophytic fungus Trichothecium crotocinigenum by bioguided isolation. Their structures were elucidated by extensive spectroscopic methods, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compounds 1 and 2 are trichothecenes possessing new ring systems. Compound 3 possesses a novel 6/6–5/5/5 fused ring system. Compounds 1–3 showed antiphytopathogenic activities with MIC values of 8–128 μg/mL.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03735