Persistent Reduction of Mucin Production after Bronchial Thermoplasty in Severe Asthma

To the Editor: Bronchial thermoplasty (BT) has been shown to reduce airway mucosa smooth muscle mass, reticular basement membrane thickness (1-3), and epithelium nerve fibers (4). Because an improvement of bronchial epithelial integrity was reported after BT, suggesting that it induces an epithelium...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2019-02, Vol.199 (4), p.536-538
Main Authors: Haj Salem, Ikhlass, Gras, Delphine, Joubert, Philippe, Boulet, Louis-Philippe, Lampron, Noel, Martel, Simon, Godbout, Krystelle, Chanez, Pascal, Laviolette, Michel, Chakir, Jamila
Format: Article
Language:English
Subjects:
Asthma
Asthma - metabolism
Asthma - surgery
Biopsy
Bronchial Thermoplasty - adverse effects
Cell adhesion & migration
Cell growth
Female
Humans
Male
Middle Aged
Mucins - metabolism
Respiratory Mucosa - metabolism
Smooth muscle
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Summary:To the Editor: Bronchial thermoplasty (BT) has been shown to reduce airway mucosa smooth muscle mass, reticular basement membrane thickness (1-3), and epithelium nerve fibers (4). Because an improvement of bronchial epithelial integrity was reported after BT, suggesting that it induces an epithelium injury-repair cycle (5), we evaluated the effects of BT on airway cell regeneration and proliferation, and mucin MUC5AC and IL-13 expression. Because they showed a persisting expansion after BT, we evaluated their proliferation. [...]in severe asthma, the bronchial epithelium could be considered as an important target of BT treatment.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201811-2064le