In vitro nematicidal activity of natural and semisynthetic cadinenes from Heterotheca inuloides against the plant‐parasitic nematode Nacobbus aberrans (Tylenchida: Pratylenchidae)

• Published in: Pest management science 2019-06, Vol.75 (6), p.1734-1742
• Main Authors: Rodríguez‐Chávez, José Luis, Franco‐Navarro, Francisco, Delgado, Guillermo
• Format: Article
• Language: English
• Subjects: Aberration; Bioactive compounds; biocontrol; cadinenes; Control methods; Derivatives; Economic impact; Eggs; false root‐knot nematode; Flowers; Hatching; Heterotheca inuloides; Hydroxyl groups; Metabolites; Mexican arnica; Nacobbus aberrans; Natural products; nematicidal activity; Nematodes; Organic chemistry; Pest control; Pratylenchidae; Quinones; Sesquiterpenes; Tylenchida
• ISSN: 1526-498X; 1526-4998
• DOI: 10.1002/ps.5294

BACKGROUND Nacobbus aberrans (Tylenchida: Pratylenchidae) is one of the main plant‐parasitic nematodes species that affects crops in Mexico, generating substantial economic losses. Traditionally, the control of the nematodes is carried out using chemical products; however, research efforts are presently focused on the search for new methods for the control of this pest. Natural products derived from plants are an alternative for the control of populations of plant‐parasitic nematodes. The genus Heterotheca (Asteraceae) is characterized by containing sesquiterpenes with cadinane skeleton, and some species of this genus exert nematicidal activity. RESULTS We determined the effects of selected Heterotheca inuloides plant metabolites and some semisynthetic derivatives on the hatching of eggs isolated from the gelatinous matrix and infective second‐stage juveniles (J2) of the false root‐knot nematode N. aberrans using an in vitro experimental model. Among the evaluated compounds, nematodes were more susceptible to hydroxylated and quinone compounds, whereas the remaining compounds showed moderate or no activity. The presence of the hydroxyl group is essential for nematicidal potential, with changes at the hydroxyl group modifying the nematicidal activity. CONCLUSION Flowers of Heterotheca inuloides contain bioactive compounds that showed nematicidal activity against N. aberrans. Here we report the nematicidal activities of cadinenes isolated from the flowers of H. inuloides and their semisynthetic derivatives against the false root‐knot nematode N. aberrans. © 2018 Society of Chemical Industry Flowers of Heterotheca inuloides contain bioactive cadinane sesquiterpenes that showed nematicidal properties against the nematode Nacobbus aberrans.