Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database

Background The purpose of this study was to investigate the prognostic factors and the value of surgical treatment of patients with newly diagnosed laryngeal cancer with distant metastasis (DM). Methods The Surveillance, Epidemiology and End Result database (SEER) was used to analyze 446 patients wi...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2019-01, Vol.276 (1), p.193-201
Main Authors: Pan, Yafeng, Hong, Yuming, Liang, Zhenyuan, Zhuang, Wei
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Female
Follow-Up Studies
Head and Neck Surgery
Humans
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Laryngology
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasm Metastasis
Neoplasm Staging
Neurosurgery
Nomograms
Otorhinolaryngology
Prognosis
Risk Factors
SEER Program
Survival Analysis
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Summary:Background The purpose of this study was to investigate the prognostic factors and the value of surgical treatment of patients with newly diagnosed laryngeal cancer with distant metastasis (DM). Methods The Surveillance, Epidemiology and End Result database (SEER) was used to analyze 446 patients with laryngeal cancer with DM at the time of initial diagnosis from 2010 to 2014.The survival prognosis of patients with DM was performed by using Kaplan–Meier and log-rank test. The prognostic factors and the effect of surgery were analyzed using the Cox regression analysis and R-language data package. Results The incidence of DM was 3.21% (446/13865). Lung was the most common distant metastatic site of laryngeal cancer (62.6%), and brain metastases had the worst prognosis in patients at 2 months. T stage and brain metastasis were independent risk factors affecting the survival ( P  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-018-5244-5