Bioactive secondary metabolites from an endophytic fungus Phoma sp. PF2 derived from Artemisia princeps Pamp

Two new isochromanone derivatives, (3 S ,4 S )-3,8-dihydroxy-6-methoxy-3,4,5-trimethylisochroman-1-one ( 1 ) and methyl ( S )-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate ( 2 ), together with six known compounds ( 3 ‒ 8 ) were isolated from the cultures of an endophytic fungus Phoma sp....

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Bibliographic Details
Published in:Journal of antibiotics 2019-03, Vol.72 (3), p.174-177
Main Authors: Kim, Jung Wha, Choi, Hyun Gyu, Song, Ji Hoon, Kang, Ki Sung, Shim, Sang Hee
Format: Article
Language:English
Subjects:
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631/154/309/2144
639/638/309/152
82/16
96/98
Animals
Antibiotics
Artemisia - microbiology
Ascomycota - growth & development
Ascomycota - isolation & purification
Ascomycota - metabolism
Bacteriology
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Circular Dichroism
Culture Media - chemistry
Cytotoxicity
Diabetes
Endophytes - growth & development
Endophytes - isolation & purification
Endophytes - metabolism
Fungi
Immunosuppressive Agents - chemistry
Immunosuppressive Agents - isolation & purification
Immunosuppressive Agents - pharmacology
Life Sciences
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Metabolites
Mice
Microbiology
Molecular Structure
Nitric oxide
Organic Chemistry
RAW 264.7 Cells
Secondary metabolites
Spectrometry, Mass, Electrospray Ionization
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Description
Summary:Two new isochromanone derivatives, (3 S ,4 S )-3,8-dihydroxy-6-methoxy-3,4,5-trimethylisochroman-1-one ( 1 ) and methyl ( S )-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate ( 2 ), together with six known compounds ( 3 ‒ 8 ) were isolated from the cultures of an endophytic fungus Phoma sp. PF2 obtained from Artemisia princeps . The chemical structures of the isolated compounds were elucidated by interpretation of spectroscopic data (1D, 2D NMR, HRESIMS, and CD) and calculation of ECD. All the isolated compounds ( 1 ‒ 8 ) showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 machrophage cells.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-018-0131-2