Accuracy of iodine density thresholds for the separation of vertebral bone metastases from healthy-appearing trabecular bone in spectral detector computed tomography

Purpose To evaluate quantitative iodine density mapping (IDM) with spectral detector computed tomography (SDCT) as a quantitative biomarker for separation of vertebral trabecular bone metastases (BM) from healthy-appearing trabecular bone (HTB). Materials and methods IRB-approved retrospective singl...

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Bibliographic Details
Published in:European radiology 2019-06, Vol.29 (6), p.3253-3261
Main Authors: Borggrefe, Jan, Neuhaus, Victor-Frederic, Le Blanc, Markus, Grosse Hokamp, Nils, Maus, Volker, Mpotsaris, Anastasios, Lennartz, Simon, Pinto dos Santos, Daniel, Maintz, David, Abdullayev, Nuran
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Biomarkers
Blood vessels
Bone Density
Bone imaging
Bone lesions
Bone marrow
Bone mineral density
Cancellous bone
Cancellous Bone - diagnostic imaging
Cancer
Computation
Computed tomography
Diagnostic Radiology
Female
Heterogeneity
Humans
Imaging
Internal Medicine
Interventional Radiology
Iodine
Iodine Radioisotopes
Lesions
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - pathology
Magnetic resonance imaging
Male
Mapping
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Metastases
Metastasis
Middle Aged
Multivariate Analysis
Musculoskeletal
Neuroradiology
Patients
Quantitative analysis
Radiographic Image Interpretation, Computer-Assisted
Radiology
Regression analysis
Regression models
Retrospective Studies
Scintigraphy
Sensitivity
Separation
Spinal Neoplasms - diagnostic imaging
Spinal Neoplasms - secondary
Spine
Spine (lumbar)
Statistical analysis
Statistics
Thresholds
Tomography, X-Ray Computed - methods
Ultrasound
Vertebrae
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Description
Summary:Purpose To evaluate quantitative iodine density mapping (IDM) with spectral detector computed tomography (SDCT) as a quantitative biomarker for separation of vertebral trabecular bone metastases (BM) from healthy-appearing trabecular bone (HTB). Materials and methods IRB-approved retrospective single-center-study of portal venous SDCT datasets acquired between June 2016 and March 2017. Inclusion of 43 consecutive cancer patients with BM and 40 without. Target lesions and non-affected control vertebrae were defined using follow-up imaging, MRI, and/or bone scintigraphy. ID and standard deviation were determined with ROI measures by two readers in (a) bone metastases, (b) HTB of BM patients and controls, and (c) ID of various vessels. Volumetric bone mineral density (vBMD) of the lumbar spine and age were recorded. Multivariate ROC analyses und Wilcoxon test were used to determine thresholds for separation of BM and HTB. p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-018-5843-y