Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta‐analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta‐analysis to address the imp...

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Bibliographic Details
Published in:Head & neck 2019-02, Vol.41 (2), p.542-550
Main Authors: Zhu, Yue, Liu, Haichao, Xie, Nan, Liu, Xiqiang, Huang, Hongzhang, Wang, Cheng, Hou, Jinsong
Format: Article
Language:English
Subjects:
Head & neck cancer
head and neck squamous cell carcinoma
lymph node metastasis
Lymph nodes
Medical prognosis
Meta-analysis
Metastases
Neck
Oral squamous cell carcinoma
Prognosis
prognostic factor
Squamous cell carcinoma
survival
tumor budding
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Summary:Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta‐analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta‐analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel‐Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1‐2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25462