Brominated Diphenyl Ethers Including a New Tribromoiododiphenyl Ether from the Vietnamese Marine Sponge Arenosclera sp. and Their Antibacterial Activities

A new tribromoiododiphenyl ether (1) and eight known brominated diphenyl ethers (2–9) were isolated from the MeOH extract of the sponge Arenosclera sp. collected in Vietnam, using repeated open column chromatography and preparative thin layer chromatography. The chemical structure of the new compoun...

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Bibliographic Details
Published in:Chemistry & biodiversity 2019-03, Vol.16 (3), p.e1800593-n/a
Main Authors: Ki, Dae‐Won, Awouafack, Maurice Ducret, Wong, Chin Piow, Nguyen, Hien Minh, Thai, Quang Minh, Ton Nu, Lien Huong, Morita, Hiroyuki
Format: Article
Language:English
Subjects:
antibacterial activity
Arenosclera
Bacteria
biological activity
Bromination
Chromatography
Column chromatography
Columnar structure
Ethers
Flame retardants
Klebsiella
marine sponge
Minimum inhibitory concentration
NMR
Nuclear magnetic resonance
Organic chemistry
Thin layer chromatography
tribromoiododiphenyl ether
Two dimensional analysis
Vietnam
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Summary:A new tribromoiododiphenyl ether (1) and eight known brominated diphenyl ethers (2–9) were isolated from the MeOH extract of the sponge Arenosclera sp. collected in Vietnam, using repeated open column chromatography and preparative thin layer chromatography. The chemical structure of the new compound 1 was determined by analyses of spectroscopic (1D‐ and 2D‐NMR, and MS) data and by comparison of our data with those reported in the literature. Compounds 1, 3, and 8 exhibited strong antibacterial activities against the Gram‐positive bacteria Bacillus subtilis and Staphylococcus aureus and the Gram‐negative bacterium Klebsiella pneumoniae with MIC values ranging from 0.8 to 6.3 μm, while compounds 5 and 7 only displayed activities against Gram‐positive bacteria with MIC values from 0.5 to 3.1 μm. Compound 2 showed activities against the four tested bacteria with MIC values ranging from 0.5 to 6.3 μm.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201800593