Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40 432 subjects

Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN. Me...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-03, Vol.120 (3), p.4613-4619
Main Authors: Jin, Hongyan, Huang, Yupeng, Yang, Guokang
Format: Article
Language:English
Subjects:
alpha‐adducin (α‐adducin)
Asian Continental Ancestry Group - genetics
Asians
Calmodulin-Binding Proteins - genetics
Female
gene polymorphism
Humans
hypertension (HTN)
Hypertension - ethnology
Hypertension - genetics
Male
meta‐analysis
Polymorphism, Genetic
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Summary:Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN. Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN. Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.27749