Prognostic value of C‐reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy

Background The C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the C...

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Bibliographic Details
Published in:Head & neck 2019-05, Vol.41 (5), p.1342-1350
Main Authors: Kuboki, Akihito, Kanaya, Hiroaki, Nakayama, Tsuguhisa, Konno, Wataru, Goto, Kazutaka, Nakajima, Itsuo, Kashiwagi, Takashi, Hirabayashi, Hideki, Haruna, Shin‐ichi
Format: Article
Language:English
Subjects:
Albumin
C‐reactive protein/albumin ratio
Head & neck cancer
hypopharyngeal cancer
Invasiveness
Laryngeal cancer
Multivariate analysis
Neck
postoperative survival
prognostic factor
Surgery
Throat cancer
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Summary:Background The C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the CRP/Alb ratio in clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal and laryngeal cancer. Methods We evaluated 56 patients who underwent total laryngectomy or total pharyngolaryngectomy between 2003 and 2012. Univariate and multivariate analyses were retrospectively performed to examine the prognostic value of the CRP/Alb ratio in these patients. Results The optimal cutoff value of the CRP/Alb ratio was 0.32. Multivariate analysis showed that the CRP/Alb ratio was a significant and independent predictor of poor overall and disease‐free survival. Conclusion The CRP/Alb ratio may be a novel and useful indicator for predicting postoperative outcomes in patients with hypopharyngeal and laryngeal cancer.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25565