Treatment of asthma in smokers: A questionnaire survey in Japanese clinical practice

• Published in: Respiratory investigation 2019-03, Vol.57 (2), p.126-132
• Main Authors: Saito, Hiroaki, Tsuchiya, Kimitake, Chiba, Sahoko, Ogata, Tomoyuki, Imase, Reina, Yagi, Tamon, Mishima, Yuka, Jinta, Torahiko, Saito, Kazuhito, Taki, Reiko, Isogai, Susumu, Jin, Yasuto, Kawasaki, Tsutomu, Natsume, Ichiro, Miyashita, Yoshihiro, Takagiwa, Jun, Ishiwata, Nobuo, Chiaki, Tomoshige, Kishi, Masato, Tsukada, Yoshikazu, Yamasaki, Motohisa, Inase, Naohiko, Miyazaki, Yasunari
• Format: Article
• Language: English
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenergic beta-Agonists - administration & dosage; Adult; Aged; Asthma; Asthma - drug therapy; Asthma treatment; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Japan; Japan - epidemiology; Macrolides - administration & dosage; Male; Middle Aged; Muscarinic Antagonists - administration & dosage; Prescriptions - statistics & numerical data; Smokers; Smoking; Surveys and Questionnaires; Triple therapy; Young Adult
• ISSN: 2212-5345; 2212-5353
• DOI: 10.1016/j.resinv.2018.11.001

Cigarette smoking in patients with asthma leads to poor symptom control. As patients who are current smokers have been excluded from enrollment in many clinical trials on asthma, there are few reports on the treatment in current smokers with asthma. In this study, we aimed to assess how respiratory physicians manage asthma in current smokers in Japan. Respiratory physicians in 16 Japanese hospitals answered a questionnaire on treatment for patients with asthma between December 2014 and February 2015. Medical records were reviewed for 1756 patients with asthma. The mean patient age was 61.1 years, and 62.9% of the patients were female. A total of 102 patients (5.8%) were current smokers, and 546 patients (31.1%) were former smokers. Long-acting muscarinic antagonists (LAMA) were prescribed more frequently for current smokers with asthma than for former smokers and never smokers with asthma (10.8% vs 4.6%, p = 0.01, 10.8% vs 3.8%, p < 0.01). In contrast, macrolides were prescribed more frequently for former smokers and never smokers with asthma than for current smokers with asthma (7.7% vs 1.0%, p = 0.01, 6.4% vs 1.0%, p = 0.03). Triple therapy, i.e., inhaled corticosteroids, long-acting beta agonists, and LAMA concomitantly, was prescribed for current smokers with asthma more frequently than for former smokers and never smokers with asthma (9.8% vs 4.0%, p = 0.01, 9.8% vs 3.3%, p < 0.01). According to this survey, current smokers with asthma received more intensive therapy, including LAMA, than did former smokers with asthma.