miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosis

• Published in: Inflammation research 2019-03, Vol.68 (3), p.215-221
• Main Authors: Fragoso, José Manuel, Ramírez-Bello, Julian, Martínez-Ríos, Marco Antonio, Peña-Duque, Marco Antonio, Posadas-Sánchez, Rosalinda, Delgadillo-Rodríguez, Hilda, Jiménez-Morales, Mayra, Posadas-Romero, Carlos, Vargas-Alarcón, Gilberto
• Format: Article
• Language: English
• Subjects: Alleles; Allergology; Biomedical and Life Sciences; Biomedicine; Cardiovascular disease; Coronary artery; Coronary artery disease; Coronary vessels; Dermatology; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Dyslipidemia; Exonuclease; Haplotypes; Heart diseases; Hypertension; Immunology; Implants; miRNA; Neurology; Original Research Paper; Patients; Pharmacology/Toxicology; Polymorphism; Restenosis; Rheumatology; Risk; Smoking; Stents; Surgical implants
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-018-1206-z

Objective The aim of the study was to evaluate the association of miRNA-146a G / C (rs2910164), and miRNA-196a2 C / T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent. Materials and methods The polymorphisms were determined in 218 patients with CAD who underwent coronary artery stenting (66 with restenosis and 152 without restenosis) and 611 healthy controls using 5′ exonuclease TaqMan assays. Results The distribution of both polymorphisms was similar in patients with and without restenosis. However, when the whole group of patients (with and without restenosis) was compared to healthy controls, under co-dominant, dominant and additive genetic models, the T allele of the miRNA-196a2 C / T (rs11614913) polymorphism was associated with increased risk of CAD (OR = 2.18, P co–dom  = 0.006, OR = 1.86, P dom  = 0.002, and OR = 1.52, P add  = 0.002, respectively). All models were adjusted for age, type 2 diabetes mellitus, dyslipidemia, hypertension and smoking habit. The “ GT ” haplotype was associated with increased risk of developing CAD (OR = 1.36, P  = 0.046). Conclusions Our data suggests that the T allele of the miRNA-196a2 C / T (rs11614913) polymorphism is associated with the risk of developing CAD, but no association with restenosis was observed.