Important Therapeutic Considerations in T1b Penile Cancer: Prognostic Significance and Adherence to Treatment Guidelines

Background The clinical implications and contemporary management of T1b penile cancer are unknown. National treatment guidelines advocate surgical lymph node examination (SLNE) for T1b disease. Objective The aim of this study was to evaluate the prognosis of T1b disease and adherence to correspondin...

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Bibliographic Details
Published in:Annals of surgical oncology 2019-02, Vol.26 (2), p.685-691
Main Authors: Zhu, Yao, Gu, Wei-Jie, Xiao, Wen-Jun, Wang, Bei-He, Azizi, Mounsif, Spiess, Philippe E., Ye, Ding-Wei
Format: Article
Language:English
Subjects:
Circumcision
Genital cancers
Lymph nodes
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Patient compliance
Patients
Penis
Surgery
Surgical Oncology
Urologic Oncology
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Summary:Background The clinical implications and contemporary management of T1b penile cancer are unknown. National treatment guidelines advocate surgical lymph node examination (SLNE) for T1b disease. Objective The aim of this study was to evaluate the prognosis of T1b disease and adherence to corresponding treatment guidelines. Methods We analyzed 296 patients from two academic centers, and 1263 patients from the Surveillance, Epidemiology, and End Results (SEER) registry (median follow-up 48.3 and 21 months, respectively). Multivariate Cox and Fine–Gray regressions were applied for penile cancer-specific survival (PCSS) analyses. Results In the academic center cohort, 28.3% of T1 patients had T1b disease, all of whom underwent SLNE. Nodal metastases were detected in 86.7% of T1b patients and 13.2% of T1a patients ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-018-7066-5