Cardiovascular Morbidity and Mortality in Primary Sjögren's Syndrome: A Systematic Review and Meta‐Analysis

Objective Patients with immune‐mediated inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus are at increased risk of cardiovascular disease. However, the cardiovascular risk of patients with primary Sjögren's syndrome (SS) remains poorly studied. We aimed to inves...

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Bibliographic Details
Published in:Arthritis care & research (2010) 2020-01, Vol.72 (1), p.131-139
Main Authors: Beltai, Aurélie, Barnetche, Thomas, Daien, Claire, Lukas, Cedric, Gaujoux‐Viala, Cécile, Combe, Bernard, Morel, Jacques
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Congestive heart failure
Global Health
Health risk assessment
Heart rate
Humans
Inflammatory diseases
Meta-analysis
Morbidity
Morbidity - trends
Mortality
Rheumatoid arthritis
Risk Factors
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - epidemiology
Statistical analysis
Survival Rate - trends
Systematic review
Systemic lupus erythematosus
Thromboembolism
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Summary:Objective Patients with immune‐mediated inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus are at increased risk of cardiovascular disease. However, the cardiovascular risk of patients with primary Sjögren's syndrome (SS) remains poorly studied. We aimed to investigate the association between primary SS and cardiovascular morbidity and mortality. Methods We performed a systematic review of articles in Medline and the Cochrane Library and recent s from US and European meetings, searching for reports of randomized controlled studies of cardiovascular morbidity and cardiovascular mortality in primary SS. The relative risk (RR) values for cardiovascular morbidity and mortality associated with primary SS were collected and pooled in a meta‐analysis with a random‐effects model by using Review Manager (Cochrane collaboration). Results The literature search revealed 484 articles and s of interest; 14 studies (67,124 patients with primary SS) were included in the meta‐analysis. With primary SS versus control populations, the risk was significantly increased for coronary morbidity (RR 1.34 [95% confidence interval (95% CI) 1.06–1.38]; P = 0.01), cerebrovascular morbidity (RR 1.46 [95% CI 1.43–1.49]; P < 0.00001), heart failure rate (odds ratio 2.54 [95% CI 1.30–4.97]; P 
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.23821