Expression profile of long noncoding RNAs in human papillary thyroid carcinoma

Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRN...

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Bibliographic Details
Published in:Neoplasma 2019-01, Vol.66 (2), p.245-251
Main Authors: Cao, Y, Shi, C, Li, J, Liang, Y, Qiu, J, Yuan, L, Yong, Z, Zhang, D X, Shi, G Q
Format: Article
Language:English
Subjects:
Carcinogenesis
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - genetics
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Summary:Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RNAs (mRNAs) expression in human PTC and paired adjacent non-cancerous thyroid (NCT) tissues were studied by micro-array, and quantitative real-time polymerase chain reaction (qRT-PCR) validated five differentially expressed lncRNAs. We identified 2,925 significantly differentially expressed lncRNAs with potential roles in PTC, (absolute fold change >2.0; p
ISSN:0028-2685
DOI:10.4149/neo_2018_180625N414