Expression profile of long noncoding RNAs in human papillary thyroid carcinoma

Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRN...

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Published in:Neoplasma 2019-01, Vol.66 (2), p.245-251
Main Authors: Cao, Y, Shi, C, Li, J, Liang, Y, Qiu, J, Yuan, L, Yong, Z, Zhang, D X, Shi, G Q
Format: Article
Language:English
Subjects:
Carcinogenesis
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - genetics
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container_start_page 245
container_title Neoplasma
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creator Cao, Y
Shi, C
Li, J
Liang, Y
Qiu, J
Yuan, L
Yong, Z
Zhang, D X
Shi, G Q
description Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RNAs (mRNAs) expression in human PTC and paired adjacent non-cancerous thyroid (NCT) tissues were studied by micro-array, and quantitative real-time polymerase chain reaction (qRT-PCR) validated five differentially expressed lncRNAs. We identified 2,925 significantly differentially expressed lncRNAs with potential roles in PTC, (absolute fold change >2.0; p
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The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RNAs (mRNAs) expression in human PTC and paired adjacent non-cancerous thyroid (NCT) tissues were studied by micro-array, and quantitative real-time polymerase chain reaction (qRT-PCR) validated five differentially expressed lncRNAs. We identified 2,925 significantly differentially expressed lncRNAs with potential roles in PTC, (absolute fold change &gt;2.0; p&lt;0.05). Of these, 1,922 were up-regulated and 933 down-regulated and the qRT-PCR results agreed with micro-array results. Gene ontology (GO) enrichment and pathway analysis then investigated gene function and identified significantly enriched pathways in differentially expressed mRNA's. Many of these pathways were related to cancer, including 60 genes associated with "pathways in cancer" and 34 linked to "proteoglycans in cancer". Co-expression network and target prediction analysis of lncRNAs revealed that TCONS_00020457 can have important roles in PTC. 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subjects Carcinogenesis
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - genetics
title Expression profile of long noncoding RNAs in human papillary thyroid carcinoma
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