Hepatocellular carcinoma: resection with adjuvant hepatic artery infusion therapy vs resection alone. A systematic review and meta‐analysis

Hepatocellular carcinoma (HCC) has a recurrence rate of up to 70% in 5 years after resection, detrimentally lowering survival. The role of adjuvant therapy remains controversial; therefore, the aim of this study was to evaluate the disease‐free and overall survival of patients with HCC, not candidat...

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Bibliographic Details
Published in:Journal of surgical oncology 2019-03, Vol.119 (4), p.455-463
Main Authors: Moran, Alexandra, Ramos, Lorena Flor, Picado, Omar, Pendola, Fiorella, Sleeman, Danny, Dudeja, Vikas, Merchant, Nipun, Yakoub, Danny
Format: Article
Language:English
Subjects:
adjuvant hepatic artery infusion therapy (HAIT)
Aged
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Cancer surgery
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Hepatic Artery
hepatocellular carcinoma (HCC)
Humans
Infusions, Intra-Arterial
Intravenous therapy
Liver cancer
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Meta-analysis
Middle Aged
resection
Systematic review
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Summary:Hepatocellular carcinoma (HCC) has a recurrence rate of up to 70% in 5 years after resection, detrimentally lowering survival. The role of adjuvant therapy remains controversial; therefore, the aim of this study was to evaluate the disease‐free and overall survival of patients with HCC, not candidates for transplantation, undergoing resection and adjuvant hepatic artery infusion therapy vs resection alone. Our meta‐analysis showed that adjuvant HAIC improves overall and disease‐free survival after resection, especially in tumors ≥7 cm.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.25338