Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(i) migration

A novel multicomponent coupling reaction involving the iridium-catalyzed 1,5-difunctionalization of 1,3-enynes with arylboronic acids and triazinanes is described. A key step in this 1,5-(aryl)aminomethylation reaction is the alkenyl-to-allyl 1,4-iridium(i) migration.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (6), p.838-841
Main Authors: Ruscoe, Rebecca E, Callingham, Michael, Baker, Joshua A, Korkis, Stamatis E, Lam, Hon Wai
Format: Article
Language:English
Subjects:
Aromatic compounds
Coupling (molecular)
Iridium
Migration
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Description
Summary:A novel multicomponent coupling reaction involving the iridium-catalyzed 1,5-difunctionalization of 1,3-enynes with arylboronic acids and triazinanes is described. A key step in this 1,5-(aryl)aminomethylation reaction is the alkenyl-to-allyl 1,4-iridium(i) migration.
ISSN:1359-7345
1364-548X
DOI:10.1039/C8CC09238A