New directions in penile cancer

The investigators screened the published literature for cases of penile cancer and penile intraepithelial neoplasia and collated their findings with reports of human papillomavirus (HPV) DNA and p16INK4a positivity. First and foremost is the fact that the search was restricted to reports or presenta...

Full description

Saved in:
Bibliographic Details
Published in:The lancet oncology 2019-01, Vol.20 (1), p.16-17
Main Authors: Johnstone, Peter A S, Spiess, Philippe E, Giuliano, Anna R
Format: Article
Language:English
Subjects:
Cancer
Circumcision
Cyclin-Dependent Kinase Inhibitor p16
Deoxyribonucleic acid
Disease prevention
DNA
Genital cancers
Human papillomavirus
Humans
Immunization
INK4a protein
Male
p16 Protein
Papillomavirus Infections
Penile Neoplasms
Penis
Prevalence
Vaccination
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The investigators screened the published literature for cases of penile cancer and penile intraepithelial neoplasia and collated their findings with reports of human papillomavirus (HPV) DNA and p16INK4a positivity. First and foremost is the fact that the search was restricted to reports or presentations published in the English language; second, the articles included must have been published in a peer-reviewed journal; and finally, the journal must have been searchable using a conventional medical search engine. In the only HPV vaccine trial done in men to assess clinical efficacy of the vaccine, the four-valent HPV vaccine showed robust efficacy against external genital HPV infection persistence and condylomata.2,3 Although penile intraepithelial neoplasia was only observed in men randomly assigned to the placebo group of the trial, the low total penile intraepithelial neoplasia case count prohibited a formal evaluation of efficacy, and as such no indication exists for vaccination for the prevention of penile cancer.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(18)30695-8