Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer

•The G allele at rs9879992 in GSK3β was a risk factor for oral cancer (p = 0.02).•The A allele of rs1533767 (WNT11) showed a protective effect for oral cancer (p = 0.04).•The A allele of rs987525 was associated with increase risk in early stage of breast cancer (p = 0.02).•SNP-SNP interactions conta...

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Published in:Archives of oral biology 2019-03, Vol.99, p.9-14
Main Authors: de Freitas, Edimilson Martins, Machado, Renato Assis, de Moura Santos, Edilmar, de Matos, Felipe Rodrigues, Galvão, Hébel Cavalcanti, Miranda Soares, Priscila Bernardina, Freitas, Roseana de Almeida, Martelli-Júnior, Hercílio
Format: Article
Language:English
Subjects:
8q24
Breast cancer
GSK3β
IRF6
Oral cancer
Oral cleft
WNT11
WNT3A
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Summary:•The G allele at rs9879992 in GSK3β was a risk factor for oral cancer (p = 0.02).•The A allele of rs1533767 (WNT11) showed a protective effect for oral cancer (p = 0.04).•The A allele of rs987525 was associated with increase risk in early stage of breast cancer (p = 0.02).•SNP-SNP interactions containing GSK3β rs9879992 were significantly associated with oral cancer risk.•Interactions involving rs1533767, rs708111, rs642961 and rs9879992 were significantly associated with breast cancer risk. To evaluate the association of single nucleotide polymorphisms (SNPs) in genes/loci consistently altered in nonsyndromic oral clefts in patients with oral and breast cancer in a Brazilian population. This case-control study evaluated the association of SNPs in IRF6 (rs642961), WNT3A (rs708111), GSK3β (rs9879992), 8q24 (rs987525) and WNT11 (rs1533767), representing regions consistently identified as of susceptibility for oral clefts, with oral cancer (oral squamous cell carcinoma) and breast cancer. Logistic regression analyses were used for confounding adjustments, and p values ≤0.01 were considered statistically significant (Bonferroni correction = 0.05/5 polymorphic markers). The minor G allele of rs9879992 in GSK3β was associated with oral cancer risk (p = 0.02), whereas rs1533767 in WNT11 showed a protective effect against it (p = 0.04). Several SNP-SNP interactions containing GSK3β rs9879992 were significantly associated with oral cancer after 1000 permutation test. To breast cancer, the A allele of rs987525 was associated with increase risk in early stage (p = 0.02) and SNP-SNP interactions involving the 5 SNPs were significantly observed, with the most significant interaction among rs708111, rs1533767, rs9879992 and rs642961 (p1000permutation
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2018.12.004