Morphofunctional parameters of rat somatotrophes after acute and repeated immobilization or restraint stress

It is well known that stress changes levels of pituitary hormones in the bloodstream and in the pituitary itself. However, almost nothing is known about the impact of stress on histological and stereological parameters of the growth hormone producing cells (somatotrophs-GH cells). The aim of the pre...

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Bibliographic Details
Published in:Acta histochemica 2019-01, Vol.121 (1), p.29-34
Main Authors: Trifunović, Svetlana, Lakić, Iva, Vujović, Predrag, Jevdjović, Tanja, Šošić-Jurjević, Branka, Milošević, Verica, Djordjević, Jelena
Format: Article
Language:English
Subjects:
Acute and repeated stress
Growth hormone
Histology
Pituitary
Somatotrophs
Stereology
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Summary:It is well known that stress changes levels of pituitary hormones in the bloodstream and in the pituitary itself. However, almost nothing is known about the impact of stress on histological and stereological parameters of the growth hormone producing cells (somatotrophs-GH cells). The aim of the present study was to investigate the effect of: acute and repeated immobilization; acute and repeated restraint on histological and morphofunctional parameters of somatotrophs in adult Wistar rats. Changes in the pituitary gland volume; the volume density and volume of somatotrophs following acute and repeated immobilization (IMO, R-IMO); acute and repeated restraint (R, R-R) were evaluated using a stereological system (newCAST), while growth hormone level within pituitary was determined by Western blot. Our results demonstrated the decrease (p 
ISSN:0065-1281
1618-0372
DOI:10.1016/j.acthis.2018.10.003