Green synthesis of ultra-small VOx nanodots for acidic-activated HSP60 inhibition and therapeutic enhancement

Using metal oxide semiconductor nanomaterials for synergistic cancer treatment has recently attracted the attention of numerous researchers. Herein, oxygen-defective vanadium oxide nanodots (VOx NDs) with ultra-small size and great dispersibility were synthesized via a novel user-friendly method, an...

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Bibliographic Details
Published in:Biomaterials 2019-02, Vol.194, p.94-104
Main Authors: Mao, Fang, Liu, Yuxin, Ma, Liyi, Liu, Lidong, Jiang, Anqi, Zhai, Xuejiao, Zhou, Jing
Format: Article
Language:English
Subjects:
Heat shock protein
pH-responsive
Photothermal
Synergistic therapy
Vanadium oxide
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Summary:Using metal oxide semiconductor nanomaterials for synergistic cancer treatment has recently attracted the attention of numerous researchers. Herein, oxygen-defective vanadium oxide nanodots (VOx NDs) with ultra-small size and great dispersibility were synthesized via a novel user-friendly method, and then doxorubicin was loaded onto the VOx NDs surfaces. The VOx NDs had great photothermal conversion efficiency and stability. Doxorubicin-loaded VOx NDs can simultaneously serve as therapeutic agent and tumor microenvironment-activable HSP60 inhibitor, resulting in improved efficacy of photothermal therapy and released active doxorubicin for chemotherapy. Finally, we show that synergistic treatment achieved significant therapeutic effects in mice. These results provided a promising strategy for developing novel methods of synthesizing metal oxide semiconductors for enhanced synergistic cancer treatment.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2018.12.022