Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes

Whey protein and guar gum have both been reported to reduce postprandial glycemia in health and type 2 diabetes, associated with stimulation of glucagon-like peptide-1 (GLP-1) and/or slowing of gastric emptying. Our aim was to evaluate, in type 2 diabetes, the acute effects of low dose “preloads” of...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2019-12, Vol.38 (6), p.2827-2832
Main Authors: Watson, Linda E., Phillips, Liza K., Wu, Tongzhi, Bound, Michelle J., Checklin, Helen, Grivell, Jacqueline, Jones, Karen L., Horowitz, Michael, Rayner, Christopher K.
Format: Article
Language:English
Subjects:
Gastric emptying
Guar gum
Incretin hormones
Postprandial glycemia
Type 2 diabetes
Whey protein
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container_end_page 2832
container_issue 6
container_start_page 2827
container_title Clinical nutrition (Edinburgh, Scotland)
container_volume 38
creator Watson, Linda E.
Phillips, Liza K.
Wu, Tongzhi
Bound, Michelle J.
Checklin, Helen
Grivell, Jacqueline
Jones, Karen L.
Horowitz, Michael
Rayner, Christopher K.
description Whey protein and guar gum have both been reported to reduce postprandial glycemia in health and type 2 diabetes, associated with stimulation of glucagon-like peptide-1 (GLP-1) and/or slowing of gastric emptying. Our aim was to evaluate, in type 2 diabetes, the acute effects of low dose “preloads” of whey and guar, given alone or in combination before a meal, on postprandial glycemia, insulin, GLP-1, and gastric emptying. 21 patients with type 2 diabetes, managed by diet or metformin alone, were each studied on 4 days. They received a preload “shake” 15min before a mashed potato meal (368.5 kcal) labeled with 13C-octanoic-acid. The preloads comprised either (i) 17 g whey (W), (ii) 5 g guar (G), (iii) 17 g whey + 5 g guar (WG) each sweetened with 60 mg sucralose, and (iv) 60 mg sucralose alone (control; C), all dissolved in 150 mL water. Venous blood was sampled frequently for measurements of glucose, insulin, and GLP-1 concentrations. Gastric half-emptying time (T50) was calculated from breath 13CO2 excretion over 240 min. Postprandial blood glucose concentrations were lower with W and WG compared to C (each P 
doi_str_mv 10.1016/j.clnu.2018.12.014
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source ScienceDirect Freedom Collection
subjects Gastric emptying
Guar gum
Incretin hormones
Postprandial glycemia
Type 2 diabetes
Whey protein
title Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes
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