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Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database
Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy. To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease. Ele...
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| Published in: | Digestive and liver disease 2019-05, Vol.51 (5), p.724-729 |
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| container_title | Digestive and liver disease |
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| creator | Marzioni, Marco Bassanelli, Chiara Ripellino, Claudio Urbinati, Duccio Alvaro, Domenico |
| description | Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy.
To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease.
Electronic medical records from 900 general practitioners (part of the QuintilesIMS™ Longitudinal Patient Databases) were examined. Demographics were compared with those from the Italian National Institute of Statistics dataset. The International Classification of Diseases, Ninth Revision, biliary cirrhosis code 571.6 was used for diagnosis, and data on comorbidities, concomitant medications, medical examinations, specialist referrals, and treatments were collected.
This dataset was representative of the Italian population. Point prevalence of primary biliary cholangitis was calculated as 27.90 per 100,000 and incidence as 5.31 per 100,000 inhabitants/year. Some associations between the disease and comorbidities were sex specific. The most common laboratory assays requested were for liver enzymes, and the majority of patients were not referred to a specialist. Ursodeoxycholic acid was the most common therapy.
This can be used as a benchmark for monitoring and identifying unmet needs to improve treatment in Italy. |
| doi_str_mv | 10.1016/j.dld.2018.11.008 |
| format | article |
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To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease.
Electronic medical records from 900 general practitioners (part of the QuintilesIMS™ Longitudinal Patient Databases) were examined. Demographics were compared with those from the Italian National Institute of Statistics dataset. The International Classification of Diseases, Ninth Revision, biliary cirrhosis code 571.6 was used for diagnosis, and data on comorbidities, concomitant medications, medical examinations, specialist referrals, and treatments were collected.
This dataset was representative of the Italian population. Point prevalence of primary biliary cholangitis was calculated as 27.90 per 100,000 and incidence as 5.31 per 100,000 inhabitants/year. Some associations between the disease and comorbidities were sex specific. The most common laboratory assays requested were for liver enzymes, and the majority of patients were not referred to a specialist. Ursodeoxycholic acid was the most common therapy.
This can be used as a benchmark for monitoring and identifying unmet needs to improve treatment in Italy.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2018.11.008</identifier><identifier>PMID: 30584000</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Cholagogues and Choleretics - therapeutic use ; Comorbidity ; Databases, Factual ; End Stage Liver Disease - etiology ; Female ; Humans ; Incidence ; Italy - epidemiology ; Liver Cirrhosis, Biliary - drug therapy ; Liver Cirrhosis, Biliary - epidemiology ; Male ; Middle Aged ; Obeticholic acid ; Ursodeoxycholic acid ; Ursodeoxycholic Acid - therapeutic use</subject><ispartof>Digestive and liver disease, 2019-05, Vol.51 (5), p.724-729</ispartof><rights>2018 The Authors</rights><rights>Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-e47e97d39ec960bfd389db49f711140bbfafc3fd7c9b3ef4b4b9ceaa98081f3</citedby><cites>FETCH-LOGICAL-c462t-e47e97d39ec960bfd389db49f711140bbfafc3fd7c9b3ef4b4b9ceaa98081f3</cites><orcidid>0000-0003-3771-9644</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30584000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marzioni, Marco</creatorcontrib><creatorcontrib>Bassanelli, Chiara</creatorcontrib><creatorcontrib>Ripellino, Claudio</creatorcontrib><creatorcontrib>Urbinati, Duccio</creatorcontrib><creatorcontrib>Alvaro, Domenico</creatorcontrib><title>Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy.
To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease.
Electronic medical records from 900 general practitioners (part of the QuintilesIMS™ Longitudinal Patient Databases) were examined. Demographics were compared with those from the Italian National Institute of Statistics dataset. The International Classification of Diseases, Ninth Revision, biliary cirrhosis code 571.6 was used for diagnosis, and data on comorbidities, concomitant medications, medical examinations, specialist referrals, and treatments were collected.
This dataset was representative of the Italian population. Point prevalence of primary biliary cholangitis was calculated as 27.90 per 100,000 and incidence as 5.31 per 100,000 inhabitants/year. Some associations between the disease and comorbidities were sex specific. The most common laboratory assays requested were for liver enzymes, and the majority of patients were not referred to a specialist. Ursodeoxycholic acid was the most common therapy.
This can be used as a benchmark for monitoring and identifying unmet needs to improve treatment in Italy.</description><subject>Adult</subject><subject>Aged</subject><subject>Cholagogues and Choleretics - therapeutic use</subject><subject>Comorbidity</subject><subject>Databases, Factual</subject><subject>End Stage Liver Disease - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Liver Cirrhosis, Biliary - drug therapy</subject><subject>Liver Cirrhosis, Biliary - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obeticholic acid</subject><subject>Ursodeoxycholic acid</subject><subject>Ursodeoxycholic Acid - therapeutic use</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kDtvGzEQhAkjgeXY_gFuDJZp7rK8J5lUgSE7BgykSBpXBB9LmQJPVMiTDf17U5CSMtVsMTPY-Qi5YVAzYMOXdW2DrRtgvGasBuBn5ILxkVdtPzQfyt0LqPjQ8wX5lPMaoGFDD-dk0ULPOwC4IM_Lrbc4-Rjiak-jo9vkJ5X2VPvgD2peYlCblZ99pn5DH2cV9l_p8rWkNgapS3GiiiZUoXqLKVhq1ay0ynhFPjoVMl6f9JL8ul_-vvtRPf18eLz7_lSZbmjmCrsRxWhbgUYMoJ1tubC6E25kjHWgtVPOtM6ORugWXac7LQwqJThw5tpL8vnYuk3xzw7zLCefDYbyM8ZdlmUxtAPvm75Y2dFqUsw5oZOnrZKBPPCUa1l4ygNPyZgsPEvm9lS_0xPaf4m_AIvh29GAZeKrxySz8Qcy1ic0s7TR_6f-HQx1hzQ</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Marzioni, Marco</creator><creator>Bassanelli, Chiara</creator><creator>Ripellino, Claudio</creator><creator>Urbinati, Duccio</creator><creator>Alvaro, Domenico</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3771-9644</orcidid></search><sort><creationdate>201905</creationdate><title>Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database</title><author>Marzioni, Marco ; Bassanelli, Chiara ; Ripellino, Claudio ; Urbinati, Duccio ; Alvaro, Domenico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-e47e97d39ec960bfd389db49f711140bbfafc3fd7c9b3ef4b4b9ceaa98081f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cholagogues and Choleretics - therapeutic use</topic><topic>Comorbidity</topic><topic>Databases, Factual</topic><topic>End Stage Liver Disease - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Liver Cirrhosis, Biliary - drug therapy</topic><topic>Liver Cirrhosis, Biliary - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obeticholic acid</topic><topic>Ursodeoxycholic acid</topic><topic>Ursodeoxycholic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marzioni, Marco</creatorcontrib><creatorcontrib>Bassanelli, Chiara</creatorcontrib><creatorcontrib>Ripellino, Claudio</creatorcontrib><creatorcontrib>Urbinati, Duccio</creatorcontrib><creatorcontrib>Alvaro, Domenico</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marzioni, Marco</au><au>Bassanelli, Chiara</au><au>Ripellino, Claudio</au><au>Urbinati, Duccio</au><au>Alvaro, Domenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2019-05</date><risdate>2019</risdate><volume>51</volume><issue>5</issue><spage>724</spage><epage>729</epage><pages>724-729</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy.
To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease.
Electronic medical records from 900 general practitioners (part of the QuintilesIMS™ Longitudinal Patient Databases) were examined. Demographics were compared with those from the Italian National Institute of Statistics dataset. The International Classification of Diseases, Ninth Revision, biliary cirrhosis code 571.6 was used for diagnosis, and data on comorbidities, concomitant medications, medical examinations, specialist referrals, and treatments were collected.
This dataset was representative of the Italian population. Point prevalence of primary biliary cholangitis was calculated as 27.90 per 100,000 and incidence as 5.31 per 100,000 inhabitants/year. Some associations between the disease and comorbidities were sex specific. The most common laboratory assays requested were for liver enzymes, and the majority of patients were not referred to a specialist. Ursodeoxycholic acid was the most common therapy.
This can be used as a benchmark for monitoring and identifying unmet needs to improve treatment in Italy.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30584000</pmid><doi>10.1016/j.dld.2018.11.008</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3771-9644</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Aged Cholagogues and Choleretics - therapeutic use Comorbidity Databases, Factual End Stage Liver Disease - etiology Female Humans Incidence Italy - epidemiology Liver Cirrhosis, Biliary - drug therapy Liver Cirrhosis, Biliary - epidemiology Male Middle Aged Obeticholic acid Ursodeoxycholic acid Ursodeoxycholic Acid - therapeutic use |
| title | Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database |
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