Randomized clinical trial with topical diltiazem for post-hemorrhoidectomy wound healing

Anal sphincter spasm contributes to the delay in surgical wound healing after hemorrhoidectomy. A prospective, experimental, randomized, double-blind trial was conducted on two groups of patients that underwent closed hemorrhoidectomy. There were 26 patients in each group. Group A received topical d...

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Bibliographic Details
Published in:Revista de Gastroenterología de México (English Edition) 2019-01, Vol.84 (1), p.119-122
Main Authors: Rodríguez-Wong, U, Rodríguez-Medina, U, Medina-Murillo, G R
Format: Article
Language:eng ; spa
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Summary:Anal sphincter spasm contributes to the delay in surgical wound healing after hemorrhoidectomy. A prospective, experimental, randomized, double-blind trial was conducted on two groups of patients that underwent closed hemorrhoidectomy. There were 26 patients in each group. Group A received topical diltiazem in the anal region three times a day. Group B received a placebo. Cicatrization time was documented for 6 weeks through digital photography. Mean healing time for the group treated with diltiazem was 3.19 weeks (22.33±0.884 days) and 3.92 weeks (27.44±1.130 days) for the control group (p=0.012 95% CI). At week three, the wounds in 73.07% of the patients in the diltiazem group had healed, compared with 46.15% of the patients in the control group.
ISSN:0375-0906
2255-534X
DOI:10.1016/j.rgmx.2018.10.001