Ultrasonic energy-assisted preparation of β-cyclodextrin-carbon nanofiber composite: Application for electrochemical sensing of nitrofurantoin

• Published in: Ultrasonics sonochemistry 2019-04, Vol.52, p.391-400
• Main Authors: Balasubramanian, Paramasivam, Annalakshmi, Muthaiah, Chen, Shen-Ming, Sathesh, Tamilarasan, Balamurugan, T.S.T.
• Format: Article
• Language: English
• Subjects: Antimicrobial drug; Electrochemical detection; Host–guest interaction; Hydrophilic polymers; Sonochemical
• ISSN: 1350-4177; 1873-2828
• DOI: 10.1016/j.ultsonch.2018.12.014

•β-CD/CNF composite is prepared by using CNF and β-CD with the aid of sonication.•The large amount of oxygen functionalities of β-CD enhances the dispersion of CNF.•β-CD/CNFbased sensor can detect the nitrofurantoin upto 1.8 nM.•The practicality is studied in human blood serum and urine sample. A simple ultrasonic energy assisted synthesis of β-cyclodextrin (β-CD) supported carbon nanofiber composite (CNF) and its potential application in electrochemical sensing of antibiotic nitrofurantoin (NFT) is reported. The elemental composition and surface morphology of the β-CD/CNF composite was validated through Field emission scanning electron microscopy, energy dispersive X-ray microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The uniform enfolding of hydrophilic β-CD over CNF enhance the aqueous dispersion and offer abundant active surface to the β-CD/CNF composite. Further, the electrocatalytic efficacy of the β-CD/CNF composite is utilized to fabricate an electrochemical sensor for the high sensitive quantitative detection of NFT. Under optimized analytical conditions, the sensor displays a broad working range of 0.004–308 µM and calculated detection limit of 1.8 nM, respectively. In addition, the sensor showcased a good selectivity, storage, and working stability, with amiable reproducibility. The point-of-care applicability of the sensor was demonstrated with NFT spiked human blood serum and urine sample with reliable analytical performance. The simple, cost-effective NFT sensor based on β-CD/CNF offered outstanding analytical performance in real-world samples with higher reliability.