Characteristics of non‐alcoholic steatohepatitis among lean patients in Japan: Not uncommon and not always benign

Background and Aim To elucidate features of nonobese non‐alcoholic fatty liver disease (NAFLD), we assessed Japanese patients with NAFLD stratified by body mass index (BMI) and by sex. Methods Biopsy‐proven 762 NAFLD patients (404 men) were classified into three groups by the Japanese criteria: nono...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2019-08, Vol.34 (8), p.1404-1410
Main Authors: Tobari, Maki, Hashimoto, Estuko, Taniai, Makiko, Ikarashi, Yuuichi, Kodama, Kazuhisa, Kogiso, Tomomi, Tokushige, Katsutoshi, Takayoshi, Nishino, Hashimoto, Naotake
Format: Article
Language:English
Subjects:
Adiposity
Adult
Biopsy
Body composition
Body Mass Index
Comorbidity
Computed tomography
Cross-Sectional Studies
Fatty liver
Female
Fibrosis
gender difference
histology
Humans
Insulin
Insulin Resistance
Lipase - genetics
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver Cirrhosis - genetics
Liver Cirrhosis - physiopathology
Liver diseases
Male
Membrane Proteins - genetics
Middle Aged
NAFLD
NASH
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - physiopathology
nonobese patients
Obesity
Obesity - diagnosis
Obesity - epidemiology
Obesity - genetics
Obesity - physiopathology
Phospholipase
Polymorphism, Single Nucleotide
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Sexes
Single-nucleotide polymorphism
Skeletal muscle
Steatosis
Thinness - diagnosis
Thinness - epidemiology
Thinness - genetics
Thinness - physiopathology
Tokyo - epidemiology
Women
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Summary:Background and Aim To elucidate features of nonobese non‐alcoholic fatty liver disease (NAFLD), we assessed Japanese patients with NAFLD stratified by body mass index (BMI) and by sex. Methods Biopsy‐proven 762 NAFLD patients (404 men) were classified into three groups by the Japanese criteria: nonobese group (BMI
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14585