High diversity of Candida glabrata in a tertiary hospital-Mwanza, Tanzania

Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Among 47 mostly urogenital isolates, we found 13 sequence types,...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2019-10, Vol.57 (7), p.914-917
Main Authors: Mushi, Martha F, Gross, Uwe, Mshana, Stephen E, Bader, Oliver
Format: Article
Language:English
Subjects:
Africa
Alleles
Antifungal Agents - pharmacology
Bacterial Typing Techniques
Candida glabrata - classification
Candida glabrata - drug effects
Candida glabrata - genetics
Candidiasis - blood
Candidiasis - microbiology
Genetic Variation
Genotype
Humans
Microbial Sensitivity Tests
Multilocus Sequence Typing
Tanzania
Tertiary Care Centers
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Summary:Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Among 47 mostly urogenital isolates, we found 13 sequence types, amounting to a 27% genetic population difference. More than half of the isolates were of novel sequence types. ST18 was most predominant and had reduced susceptibility to fluconazole. There was clear segregation of STs between urine and vaginal specimen. In Tanzania, the C. glabrata population is genetically diverse, and divergent from those seen in other countries.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myy151