Antibacterial and antioxidant activity of naphthofuranquinones from the twigs of tropical mangrove Avicennia officinalis

Mangrove plants are endowed with various biologically active compounds which have potent antibacterial and antioxidant properties. In present study, a bioactivity-guided fractionation for antibacterial and antioxidant active metabolites from the twigs of Avicennia officinalis collected from Kuala Se...

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Bibliographic Details
Published in:Natural product research 2020-08, Vol.34 (16), p.2403-2406
Main Authors: Assaw, Suvik, Mohd Amir, Muhammad Isyraq Hazim, Khaw, Tyng Tyng, Bakar, Kamariah, Mohd Radzi, Siti Aisha, Mazlan, Noor Wini
Format: Article
Language:English
Subjects:
antibacterial
Antibacterial activity
Antioxidants
Avicennia officinalis
Avicenniaceae
Bacteria
Bioactive compounds
Biological activity
Cholera
Chromatography
Coliforms
DPPH radical scavenging
E coli
Enterobacter cloacae
Fractionation
Gram-negative bacteria
Gram-positive bacteria
Infections
Magnetic resonance spectroscopy
Metabolites
Minimum inhibitory concentration
Molecular structure
naphthofuranquinones
NMR
NMR spectroscopy
Nuclear magnetic resonance
Scavenging
Selectivity
Waterborne diseases
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Summary:Mangrove plants are endowed with various biologically active compounds which have potent antibacterial and antioxidant properties. In present study, a bioactivity-guided fractionation for antibacterial and antioxidant active metabolites from the twigs of Avicennia officinalis collected from Kuala Selangor Nature Park, Selangor, Malaysia gave 13 major fractions. The antibacterial activity of A. officinalis fractions using well-diffusion showed strong selectivity on the Gram-positive bacteria (Staphylococcus epidermidis, S. aureus and Bacillus subtilis) with minimum inhibition concentration (MIC) values of 0.156-5.00 mg/mL. However, no antibacterial activities were observed on the Gram-negative bacteria (Vibrio cholera, Enterobacter cloacae and Escherichia coli). The active antibacterial fractions were further isolated using several chromatographic techniques to give two naphthofuranquinones, namely, avicenol C (1) and stenocarpoquinone B (2). Meanwhile, the antioxidant activity of A. officinalis fractions were evaluated using DPPH radical scavenging assay exhibited low antioxidant activities. Molecular structure of the naphthofuranquinones was elucidated using 1 D and 2 D NMR spectroscopy.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1538220