Bloodpool SPECT as part of bone SPECT/CT in painful total knee arthroplasty (TKA): validation and potential biomarker of prosthesis biomechanics

Purpose To compare bloodpool SPECT with planar imaging in bone SPECT/CT of painful total knee arthroplasty (TKA) with respect to inter-rater agreement, confidence, prosthesis outcome, and biomechanical functioning. Methods Retrospective study of bloodpool SPECT and planar control images. Four raters...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2019-04, Vol.46 (4), p.1009-1018
Main Authors: Verschueren, Jolien, Albert, Adrien, Carp, Laurens, Ceyssens, Sarah, Huyghe, Ivan, Stroobants, Sigrid, Paycha, Frédéric, Gnanasegaran, Gopinath, Van den Wyngaert, Tim
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arthroplasty (knee)
Arthroplasty, Replacement, Knee - adverse effects
Biomarkers
Biomechanical Phenomena
Biomechanics
Biomedical materials
Bone biomechanics
Bone imaging
Cardiology
Cluster analysis
Computed tomography
Female
Femur
Gated Blood-Pool Imaging
Humans
Imaging
Joint surgery
Knee
Male
Mechanical Phenomena
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Oncology
Original Article
Orthopedics
Pain - diagnostic imaging
Pain - etiology
Prostheses
Prostheses and Implants
Radiology
Regional analysis
Retrospective Studies
Rotation
Single photon emission computed tomography
Single Photon Emission Computed Tomography Computed Tomography
Surgical implants
Survival
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Description
Summary:Purpose To compare bloodpool SPECT with planar imaging in bone SPECT/CT of painful total knee arthroplasty (TKA) with respect to inter-rater agreement, confidence, prosthesis outcome, and biomechanical functioning. Methods Retrospective study of bloodpool SPECT and planar control images. Four raters used the validated Bruderholz scheme and a 5-point scale to grade uptake. Inter-rater agreement and overall confidence scores were calculated. Variable cluster analysis was performed to identify patterns of uptake, and associations between patterns and prosthesis outcome and biomechanical functioning were examined. Results In all, 55 knees in 43 patients were analyzed (median follow-up 17 months; revision rate 21.8%). SPECT significantly improved inter-rater agreement in 24% of regions (all P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-018-4244-4