Preoperative predictive factors focused on inflammation-, nutrition-, and muscle-status in patients with upper urinary tract urothelial carcinoma undergoing nephroureterectomy

Objective The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with upper urinary tract urothelial carcinoma (UTUC) undergoing curative nephroureterectomy (NUx). Methods The study enrolled 125...

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Bibliographic Details
Published in:International journal of clinical oncology 2019-05, Vol.24 (5), p.533-545
Main Authors: Itami, Yoshitaka, Miyake, Makito, Tatsumi, Yoshihiro, Gotoh, Daisuke, Hori, Shunta, Morizawa, Yousuke, Iida, Kota, Ohnishi, Kenta, Nakai, Yasushi, Inoue, Takeshi, Anai, Satoshi, Tanaka, Nobumichi, Shimada, Keiji, Hirao, Shuya, Fujimoto, Kiyohide
Format: Article
Language:English
Subjects:
Age
Bladder cancer
Body mass index
C-reactive protein
Cancer Research
Fibrinogen
Inflammation
Lymphocytes
Medicine
Medicine & Public Health
Monocytes
Nutrition
Oncology
Original Article
Psoas muscle
Risk assessment
Sarcopenia
Skeletal muscle
Surgical Oncology
Urinary tract
Urogenital system
Urothelial carcinoma
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Summary:Objective The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with upper urinary tract urothelial carcinoma (UTUC) undergoing curative nephroureterectomy (NUx). Methods The study enrolled 125 patients and the preoperative variables assessed included age, body mass index, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), serum fibrinogen level (Fib), C-reactive protein (CRP), modified Glasgow prognostic score, serum albumin level (Alb), prognostic nutritional index (PNI), skeletal muscle index (SMI), psoas muscle index (PMI), and peak expiratory flow (PEF). The correlations among the variables and their prognostic values after NUx were evaluated. Results Five inflammation markers (NLR, MLR, PLR, Fib and CRP) were positively correlated. Fib was positively correlated with NLR, PLR and CRP, but inversely correlated with SMI. PNI was inversely correlated with age and the four inflammation markers ( p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-018-01381-y