Molecular mechanisms by which aerobic exercise induces insulin sensitivity

• Published in: Journal of cellular physiology 2019-08, Vol.234 (8), p.12385-12392
• Main Authors: Yaribeygi, Habib, Atkin, Stephen L., Simental‐Mendía, Luis E., Sahebkar, Amirhossein
• Format: Article
• Language: English
• Subjects: adipokines; Adipokines - metabolism; aerobic exercise; Aerobics; Blood Glucose - metabolism; Cell membranes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - pathology; Exercise; Exercise - physiology; Glucose; Glucose - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Inflammation; Insulin; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; insulin signal transduction; Metformin; Metformin - therapeutic use; Molecular modelling; Muscle, Skeletal - metabolism; Oxidation resistance; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Physical fitness; Sensitivity; Signal transduction; Signal Transduction - physiology; Therapeutic applications
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.28066

Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in the ADA/EASD consensus guidelines followed by metformin therapy. Aerobic exercise (AE) can increase insulin sensitivity by several molecular pathways including upregulation of insulin transporters in the cellular membrane of insulin‐dependent cells. In addition, AE improves insulin sensitivity by amelioration of the pathophysiologic pathways involved in insulin resistance such as the reduction of adipokines, inflammatory and oxidative stress responses, and improvement of insulin signal transduction via different molecular pathways. This review details the molecular pathways by which AE induces beneficial effects on insulin resistance Aerobic exercise (AE) can increase insulin sensitivity by several molecular pathways including upregulation of insulin transporters in the cellular membrane of insulin‐dependent cells. In addition, AE improves insulin sensitivity by amelioration of the pathophysiologic pathways involved in insulin resistance such as the reduction of adipokines, inflammatory and oxidative stress responses, and improvement of insulin signal transduction via different molecular pathways.